Fertility Preservation in Endometrial Cancer

What is RECAP?

RECAP (Risk of Endometrial CAncer Program) provides expert and evidence-based clinical care for young patients diagnosed with low grade endometrial cancer, or atypical hyperplasia who desire fertility-conserving treatment (delay hysterectomy).  This program brings together multiple specialties for the management of this condition and other treatable risk factors to optimize the probability of a successful pregnancy. Our RECAP program was created in 2019, and since then, we receive referrals from all across the province to see young patients with low grade endometrial cancer or atypical hyperplasia. As part of this clinic, we also provide comprehensive counseling and management for patients with Lynch syndrome who are at higher risk of endometrial and ovarian cancers.

Endometrial cancer in young patients: Endometrial cancer is the 4th most common cancer in women, and its incidence is rising at an alarming rate at 2.6% annually. Although endometrial cancer/atypical hyperplasia most commonly affects patients who are age 50 or older, the incidence of this disease is also rising in younger patients.

Watch this video about endometrial cancer in young patients:

Program objectives:

    • RECAP’s program objectives are the following:
    • Improve the quality of care for young patients with endometrial cancer/atypical hyperplasia wishing to preserve fertility
    • Build a research platform to further study the clinical characteristics of endometrial cancer
    • Establish a blood bio bank to further study the molecular characteristics of endometrial cancer
    • Enhance patients’ experience as they navigate through their cancer journey
    • Develop innovative treatments for patients with endometrial cancer

Our team

Our multidisciplinary team is a group of three Gynecologic Oncologists, Dr. Sarah Ferguson (clinical lead), Dr. Stephane Laframboise, Dr. Rachel Soyoun Kim, GP oncologist Dr. Shima Deljoomanesh, Psychologist Dr. Aliza Panjwani, Program Coordinator and a comprehensive team of certified Gynecologic Oncology nurses.  We work closely with experts in fertility, endocrinology, sleep medicine and supportive care through Adolescent and Young Adult Oncology Program.

Dr. Ferguson

Clinical Lead

Dr. Soyoun Kim

Gynecologic Oncologist

Dr. Deljoomanesh

GP Oncologist

Dr. Panjwani

Psychologist

Dr. Laframboise

Gynecologic Oncologist

Patient Testimonials:

“Working with Dr. Ferguson and Dr. Jackson was a wonderful experience. I was so grateful for their time, kindness and forward thinking. As a patient, it was important to me to preserve my fertility. When traditional therapy wasn’t working, Dr. Ferguson suggested a new, innovative treatment. Of course, the thought of surgery is always scary, but the process was delicately explained and the Dr. Ferguson and her team were there to help me weigh and understand the pros and cons. This became one of the best decisions of my life. When the transition to Dr. Jackson was made, I was extremely impressed with the sense of urgency around my case, and how efficiently my treatment was coordinated. Dr. Jackson was so thorough in explaining the process, and the after-care clinic and team was incredibly helpful. Throughout the entire process I felt wonderfully cared for and guided. In the end, this treatment has extended my fertility and allowed me live a healthier life. Truly giving me my life back. I do t know where I’d be today without Dr. Ferguson and Dr. Jackson.”
R.C. (43 yo, Endometrial cancer)

The Fertility Preservation in Endometrial Cancer Clinic provides expert and evidence-based clinical care for women with low grade endometrial cancer, or atypical hyperplasia, desiring fertility-conserving treatment. This program brings together multiple specialties for the concurrent management of this condition and other treatable risk factors to optimize the probability of a successful pregnancy.

image by Dr. S. Farooqi

Our Team:

Our team includes two Gynecologic Oncologists (Dr. Sarah Ferguson and Dr. Stéphane Laframboise), one General Practitioner (Dr. Shima Deljoomanesh), one Patient Navigator, and a team of certified Gynecologic Oncology nurses. Onsite referrals to our partnering specialties are available, including fertility, endocrinology, sleep medicine, supportive care through the Adolescent and Young Adult Oncology Program, and much more!

Dr. Sarah Ferguson, Gynecologic Oncologist
Dr. Stephane Laframboise, Gynecologic Oncologist

 

 

 

 

 

 

 

 

Our Research:

In collaboration with the Division of Gynecologic Oncology Research and the UHN Bariatric Clinic, our team has designed a new clinical trial evaluating elevated body mass index (BMI) as a risk-factor, titled Bariatric Surgery for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer Endometrium (“B-FiERCE”). This trial invites eligible patients to randomize to either receiving bariatric surgery with standard therapy or standard therapy alone. Eligible patients must have a BMI of ≥35 and remain untreated until assessed by our clinic.

If you would like to know more about our study or eligibility, please contact Gabrielle Ene at Gabrielle.Ene@uhnresearch.ca

In collaboration with the Division of Gynecologic Oncology Research and the UHN Bariatric Clinic, our team has designed a new clinical trial evaluating elevated body mass index (BMI) as a risk-factor, titled Bariatric Surgery for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer Endometrium (“B-FiERCE”). This trial invites eligible patients to randomize to either receiving bariatric surgery with standard therapy or standard therapy alone. Eligible patients must have a BMI of ≥35 and remain untreated until assessed by our clinic.

If you would like to know more about our study or eligibility, please contact goresearch@uhn.ca

Research Team

In September of 2022, Vanessa joined the Division of Gynecologic Oncology at Princess Margaret Cancer Centre. In her role as Clinical Research Manager she supports clinician-investigators in the planning, development, and initiation of new and innovative research projects, and provides oversight for all operational aspects of existing studies.

Vanessa is a Certified Clinical Research Professional (CCRP) who began her clinical research career in 2005, while finishing her Bachelor of Sciences in Biology and Psychology at the University of Western Ontario and her Graduate Certificate in Pharmaceutical Regulatory Affairs and Quality Operations at Seneca College. Upon completion, she worked in the field for several years and developed an interest in efforts aimed at reducing health disparities, particularly in women and children, who are often underrepresented in research. This was the impetus that led her to pursue a Master of Medical Science in Global Health at the Karolinska Institutet in Sweden.

Over the course of the last two decades, Vanessa has held various clinical research roles; not only has she been part of several different research teams supporting and managing studies under the direction of Principal Investigators, but she also has experience as a Research Ethics Coordinator and as a Clinical Research Quality Assurance Specialist.

Before coming to UHN/PMCC, Vanessa worked at Women’s College Hospital, Holland Bloorview Kids Rehabilitation Hospital, the Hospital for Sick Children, the Ontario Institute for Cancer Research, the Odette Cancer Centre at Sunnybrook Health Sciences Centre, and Viventia Bio (acquired by Sesen Bio). She’s also been involved in a research study in Cambodia, which was led by the Malaria Consortium.

Vanessa Ballin
Clinical Research Manager
Tara Zad
Clinical Research Analyst

Tara completed a Master of Science degree in Biology with a focus on Genetics in Parkinson’s disease at Memorial University of Newfoundland in 2019, gaining extensive experience in wet lab techniques. Immediately after, she pursued her second master’s in Clinical Epidemiology, researching the effects of opportunistic salpingectomy as a benign gynecologic surgery on ovarian cancer in the general population. This experience sparked her interest in gynecologic cancers. Coupled with her internship as a clinical research assistant at BreatheSuite, med-tech startup, she decided to pursue a career in clinical research.

In October 2023, Tara joined Princess Margaret Cancer Centre as a clinical research analyst to facilitate the conduct of both retrospective and prospective gynecologic oncology studies